副研究员,硕士生导师,研究方向:中医药抗肿瘤;妇科肿瘤与抑郁共病的证治规律研究;电子邮箱:ljdeng@jnu.edu.cn
职称:副研究员
研究方向:中医药抗肿瘤;妇科肿瘤与抑郁共病的证治规律研究
电子邮箱:ljdeng@jnu.edu.cn
博士,副研究员,硕士生导师。2017年毕业于暨南大学药学院中药药理学专业,获博士学位。2018年初进入beat365手机客户端(亚洲)集团有限公司工作。主持国家级课题、省部级课题、厅局级课题各1项。以(共)第一/通讯作者在J Med Chem,J Leukocyte Biol,J Ethnopharmacol等本领域权威杂志发表SCI收录论文17篇,累计影响因子大于60,总引用500余次,h-index为11。主讲《中西医发展史对比研究》等课程。参与翻译论著1部。
①课题:
[1] 国家自然科学基金青年科学基金项目,81803790,蟾皮活性成分沙蟾毒精经EpCAM通路调控肝癌干细胞生物学特性的机制研,2019/01-2021/12,21万元,在研,主持。
[2] 广东省基础与应用基础研究基金自然科学基金面上项目,2020A1515011090,清热解毒中药蟾皮蟾皮活性成分活性成分抑制肝癌干细胞的分子机制研究,2019/10-2022/09,10万,在研,主持。
[3] 广东省中医药局中医药科研面上项目,逍遥散调节VPS13a 减少CUMS 模型大鼠皮质溶酶体降解的机制研究,2021/01-2023/12,1万元,在研,主持。
②论文:
[1] Deng LJ#, Wang LH#, Li YB, Chen MF, Huang MH, Ye WC*, Zhang DM*, Chen WM*. Fibroblast activation protein alpha-activated tripeptide bufadienolide anti-tumor prodrug with reduced cardiotoxicity. Journal of Medicinal Chemistry, 2017, 60 (13): 5320-5333.
[2] Gan H, Lei YH, Yuan NJ, Tang KR, Hao WZ, Ma QY, Wu MS, Zhou X, Li XJ, Huang JQ, Deng LJ* Chen JX*, Circular RNAs in Depression: Biogenesis, Function, Expression, and Therapeutic potential. Biomedicine & Pharmacotherapy. 137, (2021), 111244
[3] DengLJ#, Qi M#, Li N#, L ei YH, Zhang DM, Chen JX*. Natural products and their derivatives: promising modulators of tumor immunotherapy.Journal of Leukocyte Biology,2020, 108(2): 493-508.
[4] Deng LJ#, Lei YH#, Quan J-Y, Li BJ, Zhang DM, Tian HY, Chen Y, Zhang EX, Chen L, Ye WC, Ning WM, Yu LZ, Liu JS. 1β–OH–arenobufagin induces mitochondrial apoptosis in hepatocellular carcinoma through the suppression of mTOR signaling pathway. Journal of Ethnopharmacology, 2020,
[5] Deng LJ#, Qi M#, Peng QL, Chen MF, Qi Q, Zhang JY, Yao N, Huang MH, Li XB, Peng YH, Liu JS, Fu DR, Chen JX, Ye WC*, Zhang DM*. Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein. Cancer Cell International, 2018, 18; 18: 209.
[6] Gan H#, Qi M#, Chan C#, Pan L, Ye GN, Lei YH, Liu AA, Xue FF, Liu DD, Ye WC, Zhang DM, Deng LJ*, Chen JX*. Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo. International Journal of Oncology, 2020, 57(2): 562-573.
[7] Deng LJ#, Li Y#, Qi M, Liu JS, Wang S, Hu LJ, Lei YH, Jiang RW, Chen WM, Qi Q, Tian HY, Han WL, Wu BJ, Chen JX, Ye WC*, Zhang DM*. Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment. European Journal of Pharmacology.
https://doi.org/10.1016/j.ejphar.2020.173379.
[8] Gan L#, Zheng YR#, Deng LJ#, Sun PH, Ye JX, Wei XD, Liu FF, Yu LZ, Ye WC, Fan CL, Liu JS, Zhang WQ*. Diterpenoid lactones with anti-inflammatory effects from the aerial parts of andrographis paniculate. Molecules, 2019, 24(15): E2726.
[9] Deng LJ#, Hu LP#, Peng QL, Yang XL, Bai LL, Yiu A, Li Y, Tian HY, Ye WC*, Zhang DM*. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chemico-Biological Interactactions. 2014, 219C:184-194.
[10]Zheng J#, Deng LJ#, Chen MF, Xiao XZ, Xiao SW, Guo CP, Xiao GK, Bai LL, Ye WC, Zhang DM*, Chen HR*. Elaboration of thorough simplified vinca alkaloids as anti-mitotic agents based on pharmacophore similarity. European Journal of Medicinal Chemistry, 2013, 65: 158-167.
②其他:参与翻译中医教材1部:《中医诊断学》,人民卫生出版社
曾获“广东省药学优秀研究生学术论文”特等奖、“2016年医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会”优秀论文二等奖、“2014年医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会”优秀论文奖、和“2017国际药学研究生论坛优秀摘要奖”。
现为中华中医医药学会中药实验药理分会第五届委员会青年委员、广东省药理学会药物筛选与评价专业委会委员、广东省中医药学会肝胆疾病健康促进专业委员会委员、中国抗癌协会会员、中国药理学会会员、和广东省药理学会会员。担任Cell Cycle,上海中医药杂志等7个国内、外期刊审稿人。