基础医学（分子医学）博士，硕士研究生导师。博士毕业于中山大学肿瘤防治中心，曾赴美国加州大学洛杉矶分校（UCLA）访学2年。从事中西医结合抗恶性肿瘤、中西医结合防治抑郁症研究近十年。主持国家级课题1项，市级课题1项，厅局级课题2项，截至2020年11月已发表SCI论文14篇，最高影响因子23.29（其中第一作者/通讯作者7篇，最高影响因子8.911)。
①课题：
1. CD47+视网膜母细胞瘤干细胞自分泌SPINK1在自我更新中的作用和机制研究，国家自然科学基金青年基金，81702943，主持
2. 龙葵提取物Degalactotigonin靶向β-catenin/CD47抑制骨肉瘤干细胞的作用机制研究，广州市科技计划项目，主持
3. SPINK1 在 CD117＋/Stro1＋ 骨肉瘤干细胞中的功能及机制研究，广东省医学科研基金项目，A2018543，主持
4. 橘皮素抑制鼻咽癌干细胞的作用及机制研究，广东省中医药局科研项目，20202042，主持
②论文：
1. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018 Jan 1;24(1):130-144.
2. Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma.Mol Cancer Ther. 2013 Sep;12(9):1728-37.
3. Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway. Cancer Lett. 2014 Jan 1;342(1):150-8.
4. Feruloylated oligosaccharides and ferulic acid alter gut microbiome to alleviate diabetic syndrome. Food Research International. Volume 137, November 2020, 109410
5. Dihydromyricetin activates AMP-activated protein kinase and P38(MAPK) exerting antitumor potential in osteosarcoma. Cancer Prev Res (Phila). 2014 Sep;7(9):927-38.
6. CB-5083, an inhibitor of P97, suppresses osteosarcoma growth and stem cell properties by altering protein homeostasis. Am J Transl Res. 2020 Jun 15;12(6):2956-2967.
7. CDC20 and its downstream genes: potential prognosis factors of osteosarcoma. Int J Clin Oncol. 2019 Nov;24(11):1479-1489
8. Targeting BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. Cell Stem Cell. 2017 May 4;20(5):621-634.e6.
9. MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. Cell Cycle. 2012 Jul 1;11(13):2495-506.
10. Xiaoyaosan improves depressive-like behavior in rats with chronic immobilization stress through modulation of the gut microbiota. Biomed Pharmacother. 2019 Apr;112:108621.
11. Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma. Int J Biochem Cell Biol. 2013 Sep;45(9):1997-2006.
12. Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Int Immunopharmacol. 2019 Feb;67:186-193.
13. Digitoxin inhibits proliferation of multidrug-resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. Oncol Lett. 2020 Oct;20(4):71.
14. Repressing malic enzyme 1 redirects glucose metabolism, unbalances the redox state, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines. Chin J Cancer. 2012 Nov;31(11):519-31.